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Pim1 kinase regulates c-Kit gene translation

BACKGROUND: Receptor tyrosine kinase, c-Kit (CD117) plays a pivotal role in the maintenance and expansion of hematopoietic stem/progenitor cells (HSPCs). Additionally, over-expression and/or mutational activation of c-Kit have been implicated in numerous malignant diseases including acute myeloid le...

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Detalles Bibliográficos
Autores principales: An, Ningfei, Cen, Bo, Cai, Houjian, Song, Jin H., Kraft, Andrew, Kang, Yubin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5200960/
https://www.ncbi.nlm.nih.gov/pubmed/28042518
http://dx.doi.org/10.1186/s40164-016-0060-3