Drosophila vinculin is more harmful when hyperactive than absent, and can circumvent integrin to form adhesion complexes

Vinculin is a highly conserved protein involved in cell adhesion and mechanotransduction, and both gain and loss of its activity causes defective cell behaviour. Here, we examine how altering vinculin activity perturbs integrin function within the context of Drosophila development. Whereas loss of v...

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Detalles Bibliográficos
Autores principales: Maartens, Aidan P., Wellmann, Jutta, Wictome, Emma, Klapholz, Benjamin, Green, Hannah, Brown, Nicholas H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5201009/
https://www.ncbi.nlm.nih.gov/pubmed/27737911
http://dx.doi.org/10.1242/jcs.189878

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5201009/
https://www.ncbi.nlm.nih.gov/pubmed/27737911
http://dx.doi.org/10.1242/jcs.189878

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