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SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation

Sirtuin 2 (SIRT2) is an NAD-dependent deacetylase known to regulate microtubule dynamics and cell cycle progression. SIRT2 has also been implicated in the pathology of cancer, neurodegenerative diseases and progeria. Here, we show that SIRT2 depletion or overexpression causes nuclear envelope reasse...

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Detalles Bibliográficos
Autores principales: Kaufmann, Tanja, Kukolj, Eva, Brachner, Andreas, Beltzung, Etienne, Bruno, Melania, Kostrhon, Sebastian, Opravil, Susanne, Hudecz, Otto, Mechtler, Karl, Warren, Graham, Slade, Dea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5201015/
https://www.ncbi.nlm.nih.gov/pubmed/27875273
http://dx.doi.org/10.1242/jcs.192633
Descripción
Sumario:Sirtuin 2 (SIRT2) is an NAD-dependent deacetylase known to regulate microtubule dynamics and cell cycle progression. SIRT2 has also been implicated in the pathology of cancer, neurodegenerative diseases and progeria. Here, we show that SIRT2 depletion or overexpression causes nuclear envelope reassembly defects. We link this phenotype to the recently identified regulator of nuclear envelope reassembly ANKLE2. ANKLE2 acetylation at K302 and phosphorylation at S662 are dynamically regulated throughout the cell cycle by SIRT2 and are essential for normal nuclear envelope reassembly. The function of SIRT2 therefore extends beyond the regulation of microtubules to include the regulation of nuclear envelope dynamics.