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SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation
Sirtuin 2 (SIRT2) is an NAD-dependent deacetylase known to regulate microtubule dynamics and cell cycle progression. SIRT2 has also been implicated in the pathology of cancer, neurodegenerative diseases and progeria. Here, we show that SIRT2 depletion or overexpression causes nuclear envelope reasse...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5201015/ https://www.ncbi.nlm.nih.gov/pubmed/27875273 http://dx.doi.org/10.1242/jcs.192633 |
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author | Kaufmann, Tanja Kukolj, Eva Brachner, Andreas Beltzung, Etienne Bruno, Melania Kostrhon, Sebastian Opravil, Susanne Hudecz, Otto Mechtler, Karl Warren, Graham Slade, Dea |
author_facet | Kaufmann, Tanja Kukolj, Eva Brachner, Andreas Beltzung, Etienne Bruno, Melania Kostrhon, Sebastian Opravil, Susanne Hudecz, Otto Mechtler, Karl Warren, Graham Slade, Dea |
author_sort | Kaufmann, Tanja |
collection | PubMed |
description | Sirtuin 2 (SIRT2) is an NAD-dependent deacetylase known to regulate microtubule dynamics and cell cycle progression. SIRT2 has also been implicated in the pathology of cancer, neurodegenerative diseases and progeria. Here, we show that SIRT2 depletion or overexpression causes nuclear envelope reassembly defects. We link this phenotype to the recently identified regulator of nuclear envelope reassembly ANKLE2. ANKLE2 acetylation at K302 and phosphorylation at S662 are dynamically regulated throughout the cell cycle by SIRT2 and are essential for normal nuclear envelope reassembly. The function of SIRT2 therefore extends beyond the regulation of microtubules to include the regulation of nuclear envelope dynamics. |
format | Online Article Text |
id | pubmed-5201015 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The Company of Biologists Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-52010152017-01-23 SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation Kaufmann, Tanja Kukolj, Eva Brachner, Andreas Beltzung, Etienne Bruno, Melania Kostrhon, Sebastian Opravil, Susanne Hudecz, Otto Mechtler, Karl Warren, Graham Slade, Dea J Cell Sci Research Article Sirtuin 2 (SIRT2) is an NAD-dependent deacetylase known to regulate microtubule dynamics and cell cycle progression. SIRT2 has also been implicated in the pathology of cancer, neurodegenerative diseases and progeria. Here, we show that SIRT2 depletion or overexpression causes nuclear envelope reassembly defects. We link this phenotype to the recently identified regulator of nuclear envelope reassembly ANKLE2. ANKLE2 acetylation at K302 and phosphorylation at S662 are dynamically regulated throughout the cell cycle by SIRT2 and are essential for normal nuclear envelope reassembly. The function of SIRT2 therefore extends beyond the regulation of microtubules to include the regulation of nuclear envelope dynamics. The Company of Biologists Ltd 2016-12-15 /pmc/articles/PMC5201015/ /pubmed/27875273 http://dx.doi.org/10.1242/jcs.192633 Text en © 2016. Published by The Company of Biologists Ltd http://creativecommons.org/licenses/by/3.0This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Research Article Kaufmann, Tanja Kukolj, Eva Brachner, Andreas Beltzung, Etienne Bruno, Melania Kostrhon, Sebastian Opravil, Susanne Hudecz, Otto Mechtler, Karl Warren, Graham Slade, Dea SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation |
title | SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation |
title_full | SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation |
title_fullStr | SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation |
title_full_unstemmed | SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation |
title_short | SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation |
title_sort | sirt2 regulates nuclear envelope reassembly through ankle2 deacetylation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5201015/ https://www.ncbi.nlm.nih.gov/pubmed/27875273 http://dx.doi.org/10.1242/jcs.192633 |
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