Polymyxins facilitate entry into mammalian cells

Polymyxin B is an antibiotic used against multi-resistant Gram negative infections, despite observed nephrotoxicity. Here we report the synthesis of functionalized derivatives of polymyxin B and its per-guanidinylated derivative in order to further explore the structural requirements necessary to fa...

Descripción completa

Detalles Bibliográficos
Autores principales: Hamill, Kristina M., McCoy, Lisa S., Wexselblatt, Ezequiel, Esko, Jeffrey D., Tor, Yitzhak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5201209/
https://www.ncbi.nlm.nih.gov/pubmed/28044098
http://dx.doi.org/10.1039/c6sc00488a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5201209/
https://www.ncbi.nlm.nih.gov/pubmed/28044098
http://dx.doi.org/10.1039/c6sc00488a

Ejemplares similares