Cargando…

Polymyxins facilitate entry into mammalian cells

Polymyxin B is an antibiotic used against multi-resistant Gram negative infections, despite observed nephrotoxicity. Here we report the synthesis of functionalized derivatives of polymyxin B and its per-guanidinylated derivative in order to further explore the structural requirements necessary to fa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hamill, Kristina M., McCoy, Lisa S., Wexselblatt, Ezequiel, Esko, Jeffrey D., Tor, Yitzhak
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2016
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5201209/ https://www.ncbi.nlm.nih.gov/pubmed/28044098 http://dx.doi.org/10.1039/c6sc00488a

Ejemplares similares

On Guanidinium and Cellular Uptake
por: Wexselblatt, Ezequiel, et al.
Publicado: (2014)

Isomorphic Emissive GTP Surrogate Facilitates Initiation and Elongation of in Vitro Transcription Reactions
por: McCoy, Lisa S., et al.
Publicado: (2014)

Small molecule antagonists of cell-surface heparan sulfate and heparin–protein interactions
por: Weiss, Ryan J., et al.
Publicado: (2015)

Pt(iv) derivatives of cisplatin and oxaliplatin with phenylbutyrate axial ligands are potent cytotoxic agents that act by several mechanisms of action
por: Raveendran, Raji, et al.
Publicado: (2016)

Entry of Bunyaviruses into Mammalian Cells
por: Lozach, Pierre-Yves, et al.
Publicado: (2010)

Interactions of polymyxin B with lipopolysaccharide-containing membranes
por: Goode, Alice, et al.
Publicado: (2021)

Molecular Engineering of Polymyxin B for Imaging and Treatment of Bacterial Infections
por: Wu, Minghao, et al.
Publicado: (2022)

Glycosaminoglycan Binding Facilitates Entry of a Bacterial Pathogen into Central Nervous Systems
por: Chang, Yung-Chi, et al.
Publicado: (2011)

Expanding a fluorescent RNA alphabet: synthesis, photophysics and utility of isothiazole-derived purine nucleoside surrogates
por: Rovira, Alexander R., et al.
Publicado: (2017)

Entry of Phenuiviruses into Mammalian Host Cells
por: Koch, Jana, et al.
Publicado: (2021)

Polymyxin B engineered polystyrene-divinylbenzene microspheres for the adsorption of bilirubin and endotoxin
por: Yang, Kangle, et al.
Publicado: (2021)

Editorial: Freeze-Drying and Process Analytical Technology for Pharmaceuticals
por: Fissore, Davide, et al.
Publicado: (2018)

Molecular mechanism of inhibiting the SARS-CoV-2 cell entry facilitator TMPRSS2 with camostat and nafamostat
por: Hempel, Tim, et al.
Publicado: (2020)

Formation of typical disinfection by-products (DBPs) during chlorination and chloramination of polymyxin B sulfate
por: Wei, Xingya, et al.
Publicado: (2023)

Tetrasodium EDTA for the prevention of urinary catheter infections and blockages
por: Moore, Jessica V., et al.
Publicado: (2023)

Chikungunya virus entry and infectivity is primarily facilitated through cell line dependent attachment factors in mammalian and mosquito cells
por: Reyes Ballista, Judith Mary, et al.
Publicado: (2023)

Profiling single-cell level phagocytic activity distribution with blood lactate levels
por: Wagner, Kurt, et al.
Publicado: (2021)

The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4
por: Cai, Xingguang, et al.
Publicado: (2021)

Quality Assessment of Process Measures in Antimicrobial Stewardship: Concordance of Valacyclovir Indication and Automatic Prospective Approval in Computerized Provider Order Entry
por: Lee, Tiffany, et al.
Publicado: (2017)

Origin of bistability underlying mammalian cell cycle entry
por: Yao, Guang, et al.
Publicado: (2011)

A novel chemical biology and computational approach to expedite the discovery of new-generation polymyxins against life-threatening Acinetobacter baumannii
por: Jiang, Xukai, et al.
Publicado: (2021)

Quality Assessment of Process Measures in Antimicrobial Stewardship: Concordance of Cefepime Indication Without Automatic Prospective Approval in Computerized Provider Order Entry
por: Lee, Tiffany, et al.
Publicado: (2017)

Platelet-derived growth factor-A regulates lung fibroblast S-phase entry through p27(kip1) and FoxO3a
por: McGowan, Stephen E, et al.
Publicado: (2013)

The Difference Between Polymyxin B and Polymyxin E in Causing Skin Hyerpigmentation
por: Zou, Dongna, et al.
Publicado: (2021)

Trypanosoma cruzi: mechanism of entry and intracellular fate in mammalian cells
Publicado: (1976)

Paired immunoglobulin-like receptor B is an entry receptor for mammalian orthoreovirus
por: Shang, Pengcheng, et al.
Publicado: (2023)

Chemistry of porphyrins in fossil plants and animals
por: Tahoun, Mariam, et al.
Publicado: (2021)

Difficulty in detecting low levels of polymyxin resistance in clinical Klebsiella pneumoniae isolates: evaluation of Rapid Polymyxin NP test, Colispot Test and SuperPolymyxin medium
por: Conceição-Neto, O.C., et al.
Publicado: (2020)

Polymyxins: To Combine or Not to Combine?
por: Perez, Federico, et al.
Publicado: (2019)

Ligand entry pathways control the chemical space recognized by GPR183
por: Kjær, Viktoria Madeline Skovgaard, et al.
Publicado: (2023)

Entry and passage behavior of biological cells in a constricted compliant microchannel
por: Raj, A., et al.
Publicado: (2018)

Fabrication of polyethylene terephthalate (PET) nanoparticles with fluorescent tracers for studies in mammalian cells
por: Johnson, Leah M., et al.
Publicado: (2020)

RapidResa Polymyxin Acinetobacter NP(®) Test for Rapid Detection of Polymyxin Resistance in Acinetobacter baumannii
por: Bouvier, Maxime, et al.
Publicado: (2021)

The entry of diphtheria toxin into the mammalian cell cytoplasm: evidence for lysosomal involvement
Publicado: (1980)

Trypanosoma cruzi: Entry into Mammalian Host Cells and Parasitophorous Vacuole Formation
por: Barrias, Emile Santos, et al.
Publicado: (2013)

Advancing cell surface modification in mammalian cells with synthetic molecules
por: Yang, He, et al.
Publicado: (2023)

Ehrlichia chaffeensis Uses Its Surface Protein EtpE to Bind GPI-Anchored Protein DNase X and Trigger Entry into Mammalian Cells
por: Mohan Kumar, Dipu, et al.
Publicado: (2013)

Overview of polymyxin resistance in Enterobacteriaceae
por: da Silva, Kesia Esther, et al.
Publicado: (2022)

Thieno[3,4-d]pyrimidin-4(3H)-thione: an effective, oxygenation independent, heavy-atom-free photosensitizer for cancer cells
por: Ortiz-Rodríguez, Luis A., et al.
Publicado: (2023)

Polymyxin B Etest Fails to Distinguish Carbapenem-resistant Enterobacteriaceae with Elevated Polymyxin B MICs
por: Kulengowski, Brandon, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_uo6snhtdmh7b1s2mgos2iuphmh