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Automated Algorithm for J-T(peak) and T(peak)-T(end) Assessment of Drug-Induced Proarrhythmia Risk

BACKGROUND: Prolongation of the heart rate corrected QT (QTc) interval is a sensitive marker of torsade de pointes risk; however it is not specific as QTc prolonging drugs that block inward currents are often not associated with torsade. Recent work demonstrated that separate analysis of the heart r...

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Detalles Bibliográficos
Autores principales: Johannesen, Lars, Vicente, Jose, Hosseini, Meisam, Strauss, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5201230/
https://www.ncbi.nlm.nih.gov/pubmed/28036330
http://dx.doi.org/10.1371/journal.pone.0166925