Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block

BACKGROUND: Drugs that prolong the heart rate corrected QT interval (QTc) on the electrocardiogram (ECG) by blocking the hERG potassium channel and also block inward currents (late sodium or L-type calcium) are not associated with torsade de pointes (e.g. ranolazine and verapamil). Thus, identifying...

Descripción completa

Detalles Bibliográficos
Autores principales: Vicente, Jose, Johannesen, Lars, Hosseini, Meisam, Mason, Jay W., Sager, Philip T., Pueyo, Esther, Strauss, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5201270/
https://www.ncbi.nlm.nih.gov/pubmed/28036334
http://dx.doi.org/10.1371/journal.pone.0163619

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5201270/
https://www.ncbi.nlm.nih.gov/pubmed/28036334
http://dx.doi.org/10.1371/journal.pone.0163619

Ejemplares similares