On the Spatial Organization of mRNA, Plasmids, and Ribosomes in a Bacterial Host Overexpressing Membrane Proteins

By using fluorescence imaging, we provide a time-resolved single-cell view on coupled defects in transcription, translation, and growth during expression of heterologous membrane proteins in Lactococcus lactis. Transcripts encoding poorly produced membrane proteins accumulate in mRNA-dense bodies at...

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Detalles Bibliográficos
Autores principales: van Gijtenbeek, Lieke A., Robinson, Andrew, van Oijen, Antoine M., Poolman, Bert, Kok, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5201305/
https://www.ncbi.nlm.nih.gov/pubmed/27977669
http://dx.doi.org/10.1371/journal.pgen.1006523

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5201305/
https://www.ncbi.nlm.nih.gov/pubmed/27977669
http://dx.doi.org/10.1371/journal.pgen.1006523

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