Cargando…

Comparison of a teratogenic transcriptome-based predictive test based on human embryonic versus inducible pluripotent stem cells

BACKGROUND: Human embryonic stem cells (hESCs) partially recapitulate early embryonic three germ layer development, allowing testing of potential teratogenic hazards. Because use of hESCs is ethically debated, we investigated the potential for human induced pluripotent stem cells (hiPSCs) to replace...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shinde, Vaibhav, Perumal Srinivasan, Sureshkumar, Henry, Margit, Rotshteyn, Tamara, Hescheler, Jürgen, Rahnenführer, Jörg, Grinberg, Marianna, Meisig, Johannes, Blüthgen, Nils, Waldmann, Tanja, Leist, Marcel, Hengstler, Jan Georg, Sachinidis, Agapios
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203708/ https://www.ncbi.nlm.nih.gov/pubmed/28038682 http://dx.doi.org/10.1186/s13287-016-0449-2

Ejemplares similares

Kinetic modeling of stem cell transcriptome dynamics to identify regulatory modules of normal and disturbed neuroectodermal differentiation
por: Meisig, Johannes, et al.
Publicado: (2020)

Transcriptome-based prediction of drugs, inhibiting cardiomyogenesis in human induced pluripotent stem cells
por: Cherianidou, Anna, et al.
Publicado: (2023)

Radiation Response of Murine Embryonic Stem Cells
por: Hellweg, Christine E., et al.
Publicado: (2020)

Classification of Developmental Toxicants in a Human iPSC Transcriptomics-Based Test
por: Cherianidou, Anna, et al.
Publicado: (2022)

Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Tox(ukn) and STOP-Tox(ukk) tests
por: Shinde, Vaibhav, et al.
Publicado: (2016)

A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors
por: Rempel, Eugen, et al.
Publicado: (2015)

Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration
por: Pallocca, Giorgia, et al.
Publicado: (2015)

High Accuracy Classification of Developmental Toxicants by In Vitro Tests of Human Neuroepithelial and Cardiomyoblast Differentiation
por: Seidel, Florian, et al.
Publicado: (2022)

Depletion of Mageb16 induces differentiation of pluripotent stem cells predominantly into mesodermal derivatives
por: Gaspar, John Antonydas, et al.
Publicado: (2017)

Design Principles of Concentration-Dependent Transcriptome Deviations in Drug-Exposed Differentiating Stem Cells
por: Waldmann, Tanja, et al.
Publicado: (2014)

Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes
por: Chaudhari, Umesh, et al.
Publicado: (2017)

Impairment of human neural crest cell migration by prolonged exposure to interferon-beta
por: Pallocca, Giorgia, et al.
Publicado: (2017)

Modulation of Differentiation Processes in Murine Embryonic Stem Cells Exposed to Parabolic Flight-Induced Acute Hypergravity and Microgravity
por: Acharya, Aviseka, et al.
Publicado: (2018)

Neuronal developmental gene and miRNA signatures induced by histone deacetylase inhibitors in human embryonic stem cells
por: Meganathan, K, et al.
Publicado: (2015)

MicroRNAs as early toxicity signatures of doxorubicin in human-induced pluripotent stem cell-derived cardiomyocytes
por: Chaudhari, Umesh, et al.
Publicado: (2016)

Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells
por: Nemade, Harshal, et al.
Publicado: (2018)

Epigenetic mechanisms of Strip2 in differentiation of pluripotent stem cells
por: Srinivasan, Sureshkumar Perumal, et al.
Publicado: (2022)

STRIP2 Is Indispensable for the Onset of Embryonic Stem Cell Differentiation
por: Sabour, Davood, et al.
Publicado: (2017)

Distinct transcriptomic changes in E14.5 mouse skeletal muscle lacking RYR1 or Ca(v)1.1 converge at E18.5
por: Filipova, Dilyana, et al.
Publicado: (2018)

From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects
por: Balmer, Nina V., et al.
Publicado: (2014)

First steps towards the successful surface-based cultivation of human embryonic stem cells in hanging drop systems
por: Schulz, Julia C, et al.
Publicado: (2012)

Lineage-Specific Regulation of Epigenetic Modifier Genes in Human Liver and Brain
por: Weng, Matthias K., et al.
Publicado: (2014)

Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment
por: Chaudhari, Umesh, et al.
Publicado: (2015)

Cardiotoxicity and Heart Failure: Lessons from Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Anticancer Drugs
por: Sachinidis, Agapios
Publicado: (2020)

Differentiation and Selection of Hepatocyte Precursors in Suspension Spheroid Culture of Transgenic Murine Embryonic Stem Cells
por: Gabriel, Elke, et al.
Publicado: (2012)

Metabolite signatures of doxorubicin induced toxicity in human induced pluripotent stem cell-derived cardiomyocytes
por: Chaudhari, Umesh, et al.
Publicado: (2017)

Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay
por: Colaianna, Marilena, et al.
Publicado: (2016)

Persistence of intramyocardially transplanted murine induced pluripotent stem cell-derived cardiomyocytes from different developmental stages
por: Peinkofer, Gabriel, et al.
Publicado: (2021)

Cyclooxygenases Inhibitors Efficiently Induce Cardiomyogenesis in Human Pluripotent Stem Cells
por: Nemade, Harshal, et al.
Publicado: (2020)

Cardiovascular genomics: A current overview of in vivo and in vitro studies
por: Mariappan, Devi, et al.
Publicado: (2006)

Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach
por: Krug, Anne K., et al.
Publicado: (2012)

High-throughput base editing: a promising technology for precision medicine and drug discovery
por: Sachinidis, Agapios
Publicado: (2021)

Correction: Nemade, H.; et al. Cyclooxygenases Inhibitors Efficiently Induce Cardiomyogenesis in Human Pluripotent Stem Cells. Cells 2020, 9, 554
por: Nemade, Harshal, et al.
Publicado: (2020)

Comparison of observation-based and model-based identification of alert concentrations from concentration–expression data
por: Kappenberg, Franziska, et al.
Publicado: (2021)

Identification of Thalidomide-Specific Transcriptomics and Proteomics Signatures during Differentiation of Human Embryonic Stem Cells
por: Meganathan, Kesavan, et al.
Publicado: (2012)

Parallel Genome-wide Profiling of Coding and Non-coding RNAs to Identify Novel Regulatory Elements in Embryonic and Maturated Heart
por: Sabour, Davood, et al.
Publicado: (2018)

Establishing the Embryonic Axes: Prime Time for Teratogenic Insults
por: Sadler, Thomas W.
Publicado: (2017)

Generation of human induced pluripotent stem cell-derived cardiomyocytes in 2D monolayer and scalable 3D suspension bioreactor cultures with reduced batch-to-batch variations
por: Hamad, Sarkawt, et al.
Publicado: (2019)

Evaluation of Developmental Toxicants and Signaling Pathways in a Functional Test Based on the Migration of Human Neural Crest Cells
por: Zimmer, Bastian, et al.
Publicado: (2012)

Application of the Pluripotent Stem Cells and Genomics in Cardiovascular Research—What We Have Learnt and Not Learnt until Now
por: Simeon, Michael, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_31il2dljpltp1oodvm6075eesl