The CB(1) Neutral Antagonist AM4113 Retains the Therapeutic Efficacy of the Inverse Agonist Rimonabant for Nicotine Dependence and Weight Loss with Better Psychiatric Tolerability

BACKGROUND: Multiple studies suggest a pivotal role of the endocannabinoid system in regulating the reinforcing effects of various substances of abuse. Rimonabant, a CB(1) inverse agonist found to be effective for smoking cessation, was associated with an increased risk of anxiety and depression. He...

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Detalles Bibliográficos
Autores principales: Gueye, Aliou B., Pryslawsky, Yaroslaw, Trigo, Jose M., Poulia, Nafsika, Delis, Foteini, Antoniou, Katerina, Loureiro, Michael, Laviolette, Steve R., Vemuri, Kiran, Makriyannis, Alexandros, Le Foll, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Regular Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203757/
https://www.ncbi.nlm.nih.gov/pubmed/27493155
http://dx.doi.org/10.1093/ijnp/pyw068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203757/
https://www.ncbi.nlm.nih.gov/pubmed/27493155
http://dx.doi.org/10.1093/ijnp/pyw068

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