Ionic immune suppression within the tumour microenvironment limits T cell effector function

Tumours progress despite being infiltrated by tumour-specific effector T cells1. Tumours contain areas of cellular necrosis, which is associated with poor survival in a variety of cancers2. Here, we show that necrosis releases an intracellular ion, potassium, into the extracellular fluid of mouse an...

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Detalles Bibliográficos
Autores principales: Eil, Robert, Vodnala, Suman K, Clever, David, Klebanoff, Christopher A, Sukumar, Madhusudhanan, Pan, Jenny H, Palmer, Douglas C, Gros, Alena, Yamamoto, Tori N, Patel, Shashank J, Guittard, Geoffrey C, Yu, Zhiya, Carbonaro, Valentina, Okkenhaug, Klaus, Schrump, David S, Linehan, W Marston, Roychoudhuri, Rahul, Restifo, Nicholas P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5204372/
https://www.ncbi.nlm.nih.gov/pubmed/27626381
http://dx.doi.org/10.1038/nature19364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5204372/
https://www.ncbi.nlm.nih.gov/pubmed/27626381
http://dx.doi.org/10.1038/nature19364

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