A Naphthalenic Derivative ND-1 Inhibits Thrombus Formation by Interfering the Binding of Fibrinogen to Integrin αIIbβ3

Integrin αIIbβ3 plays a crucial role in the process of platelet aggregation. Three integrin αIIbβ3 antagonists (abciximab, eptifibatide, and tirofiban) have been approved by FDA for clinical use. Unfortunately, they all showed severe side effects such as thrombocytopenia and bleeding risk. Thus, res...

Descripción completa

Detalles Bibliográficos
Autores principales: Ding, Xue, Liu, Tong-dan, Xie, Zhou-ling, Zhao, Qi, Cao, Yuan, Liu, Xiao-dong, Wang, Cai-hui, Gamariel, Rwibasira Rudinga, Ming, Xin, Li, Zhi-yu, Kong, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206433/
https://www.ncbi.nlm.nih.gov/pubmed/28097150
http://dx.doi.org/10.1155/2016/8587164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206433/
https://www.ncbi.nlm.nih.gov/pubmed/28097150
http://dx.doi.org/10.1155/2016/8587164

Ejemplares similares