Intrinsic transcriptional heterogeneity in B cells controls early class switching to IgE

Noncoding transcripts originating upstream of the immunoglobulin constant region (I transcripts) are required to direct activation-induced deaminase to initiate class switching in B cells. Differential regulation of Iε and Iγ1 transcription in response to interleukin 4 (IL-4), hence class switching...

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Detalles Bibliográficos
Autores principales: Wu, Yee Ling, Stubbington, Michael J.T., Daly, Maria, Teichmann, Sarah A., Rada, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206502/
https://www.ncbi.nlm.nih.gov/pubmed/27994069
http://dx.doi.org/10.1084/jem.20161056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206502/
https://www.ncbi.nlm.nih.gov/pubmed/27994069
http://dx.doi.org/10.1084/jem.20161056

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