The cell cycle restricts activation-induced cytidine deaminase activity to early G1

Activation-induced cytidine deaminase (AID) converts cytosine into uracil to initiate somatic hypermutation (SHM) and class switch recombination (CSR) of antibody genes. In addition, this enzyme produces DNA lesions at off-target sites that lead to mutations and chromosome translocations. However, A...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Qiao, Kieffer-Kwon, Kyong-Rim, Oliveira, Thiago Y., Mayer, Christian T., Yao, Kaihui, Pai, Joy, Cao, Zhen, Dose, Marei, Casellas, Rafael, Jankovic, Mila, Nussenzweig, Michel C., Robbiani, Davide F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206505/
https://www.ncbi.nlm.nih.gov/pubmed/27998928
http://dx.doi.org/10.1084/jem.20161649

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206505/
https://www.ncbi.nlm.nih.gov/pubmed/27998928
http://dx.doi.org/10.1084/jem.20161649

Ejemplares similares