Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor

Pain places a devastating burden on patients and society and current pain therapeutics exhibit limitations in efficacy, unwanted side effects and the potential for drug abuse and diversion. Although genetic evidence has clearly demonstrated that the voltage-gated sodium channel, Nav1.7, is critical...

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Detalles Bibliográficos
Autores principales: Flinspach, M., Xu, Q., Piekarz, A. D., Fellows, R., Hagan, R., Gibbs, A., Liu, Y., Neff, R. A., Freedman, J., Eckert, W. A., Zhou, M., Bonesteel, R., Pennington, M. W., Eddinger, K. A., Yaksh, T. L., Hunter, M., Swanson, R. V., Wickenden, A. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206724/
https://www.ncbi.nlm.nih.gov/pubmed/28045073
http://dx.doi.org/10.1038/srep39662

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206724/
https://www.ncbi.nlm.nih.gov/pubmed/28045073
http://dx.doi.org/10.1038/srep39662

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