Calpain-dependent disruption of nucleo-cytoplasmic transport in ALS motor neurons

Nuclear dysfunction in motor neurons has been hypothesized to be a principal cause of amyotrophic lateral sclerosis (ALS) pathogenesis. Here, we investigated the mechanism by which the nuclear pore complex (NPC) is disrupted in dying motor neurons in a mechanistic ALS mouse model (adenosine deaminas...

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Detalles Bibliográficos
Autores principales: Yamashita, Takenari, Aizawa, Hitoshi, Teramoto, Sayaka, Akamatsu, Megumi, Kwak, Shin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206745/
https://www.ncbi.nlm.nih.gov/pubmed/28045133
http://dx.doi.org/10.1038/srep39994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206745/
https://www.ncbi.nlm.nih.gov/pubmed/28045133
http://dx.doi.org/10.1038/srep39994

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