Disruption of cell adhesion by an antibody targeting the cell-adhesive intermediate (X-dimer) of human P-cadherin

Human P-cadherin is a cell adhesion protein of the family of classical cadherins, the overexpression of which is correlated with poor prognosis in various types of cancer. Antibodies inhibiting cell-cell adhesion mediated by P-cadherin show clear therapeutic effect, although the mechanistic basis ex...

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Detalles Bibliográficos
Autores principales: Kudo, Shota, Caaveiro, Jose M. M., Nagatoishi, Satoru, Miyafusa, Takamitsu, Matsuura, Tadashi, Sudou, Yukio, Tsumoto, Kouhei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206748/
https://www.ncbi.nlm.nih.gov/pubmed/28045038
http://dx.doi.org/10.1038/srep39518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206748/
https://www.ncbi.nlm.nih.gov/pubmed/28045038
http://dx.doi.org/10.1038/srep39518

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