Human Metabolome-derived Cofactors Are Required for the Antibacterial Activity of Siderocalin in Urine

In human urinary tract infections, host cells release the antimicrobial protein siderocalin (SCN; also known as lipocalin-2, neutrophil gelatinase-associated lipocalin, or 24p3) into the urinary tract. By binding to ferric catechol complexes, SCN can sequester iron, a growth-limiting nutrient for mo...

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Detalles Bibliográficos
Autores principales: Shields-Cutler, Robin R., Crowley, Jan R., Miller, Connelly D., Stapleton, Ann E., Cui, Weidong, Henderson, Jeffrey P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207064/
https://www.ncbi.nlm.nih.gov/pubmed/27780864
http://dx.doi.org/10.1074/jbc.M116.759183

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207064/
https://www.ncbi.nlm.nih.gov/pubmed/27780864
http://dx.doi.org/10.1074/jbc.M116.759183

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