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Human Metabolome-derived Cofactors Are Required for the Antibacterial Activity of Siderocalin in Urine

In human urinary tract infections, host cells release the antimicrobial protein siderocalin (SCN; also known as lipocalin-2, neutrophil gelatinase-associated lipocalin, or 24p3) into the urinary tract. By binding to ferric catechol complexes, SCN can sequester iron, a growth-limiting nutrient for mo...

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Detalles Bibliográficos
Autores principales:	Shields-Cutler, Robin R., Crowley, Jan R., Miller, Connelly D., Stapleton, Ann E., Cui, Weidong, Henderson, Jeffrey P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2016
Materias:	Molecular Bases of Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207064/ https://www.ncbi.nlm.nih.gov/pubmed/27780864 http://dx.doi.org/10.1074/jbc.M116.759183

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