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Re-orienting coupling of organocuprates with propargyl electrophiles from S(N)2′ to S(N)2 with stereocontrol
Diorganocuprate(i) reagents derived from lithiated heterocycles and CuCN react with enantioenriched secondary propargyl bromides to give the corresponding propargylated heterocycles. While propargyl electrophiles typically undergo S(N)2′ displacement, this transformation represents the first example...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207346/ https://www.ncbi.nlm.nih.gov/pubmed/28066535 http://dx.doi.org/10.1039/c6sc01086e |