Normal Levels of Sox9 Expression in the Developing Mouse Testis Depend on the TES/TESCO Enhancer, but This Does Not Act Alone

During mouse sex determination, transient expression of the Y-linked gene Sry up-regulates its direct target gene Sox9, via a 3.2 kb testis specific enhancer of Sox9 (TES), which includes a core 1.4 kb element, TESCO. SOX9 activity leads to differentiation of Sertoli cells, rather than granulosa cel...

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Detalles Bibliográficos
Autores principales: Gonen, Nitzan, Quinn, Alexander, O’Neill, Helen C., Koopman, Peter, Lovell-Badge, Robin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207396/
https://www.ncbi.nlm.nih.gov/pubmed/28045957
http://dx.doi.org/10.1371/journal.pgen.1006520

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207396/
https://www.ncbi.nlm.nih.gov/pubmed/28045957
http://dx.doi.org/10.1371/journal.pgen.1006520

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