Cargando…

Altered Epithelial Gene Expression in Peripheral Airways of Severe Asthma

Management of severe asthma remains a challenge despite treatment with glucocorticosteroid therapy. The majority of studies investigating disease mechanisms in treatment-resistant severe asthma have previously focused on the large central airways, with very few utilizing transcriptomic approaches. T...

Descripción completa

Detalles Bibliográficos
Autores principales:	Singhania, Akul, Rupani, Hitasha, Jayasekera, Nivenka, Lumb, Simon, Hales, Paul, Gozzard, Neil, Davies, Donna E., Woelk, Christopher H., Howarth, Peter H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207492/ https://www.ncbi.nlm.nih.gov/pubmed/28045928 http://dx.doi.org/10.1371/journal.pone.0168680

Ejemplares similares

Peripheral airways type 2 inflammation, neutrophilia and microbial dysbiosis in severe asthma
por: Azim, Adnan, et al.
Publicado: (2021)

A MicroRNA Network Dysregulated in Asthma Controls IL-6 Production in Bronchial Epithelial Cells
por: Martinez-Nunez, Rocio T., et al.
Publicado: (2014)

IL-1α mediates cellular cross-talk in the airway epithelial mesenchymal trophic unit
por: Hill, Alison R., et al.
Publicado: (2016)

Bringing the treatable traits approach to primary care asthma management
por: Pfeffer, Paul E., et al.
Publicado: (2023)

Validation and further insight into the International Severe Asthma Registry (ISAR) eosinophil gradient algorithm in the Wessex AsThma CoHort of difficult asthma (WATCH) using historical blood eosinophil counts and induced sputum
por: Barber, Clair, et al.
Publicado: (2022)

Small RNA Species and microRNA Profiles are Altered in Severe Asthma Nanovesicles from Broncho Alveolar Lavage and Associate with Impaired Lung Function and Inflammation
por: Francisco-Garcia, Ana S., et al.
Publicado: (2019)

Recent Insights into the Management of Inflammation in Asthma
por: Rupani, Hitasha, et al.
Publicado: (2021)

Gene expression in human fungal pathogen Coccidioides immitis changes as arthroconidia differentiate into spherules and mature
por: Viriyakosol, Suganya, et al.
Publicado: (2013)

A Role for Mucolytics and Expectorants in Aiding Inhaled Therapies in Asthma? [Response To Letter]
por: Kurukulaaratchy, Ramesh J, et al.
Publicado: (2021)

Factors regulated by interferon gamma and hypoxia-inducible factor 1A contribute to responses that protect mice from Coccidioides immitis infection
por: Woelk, Christopher H, et al.
Publicado: (2012)

Barrier Disrupting Effects of Alternaria Alternata Extract on Bronchial Epithelium from Asthmatic Donors
por: Leino, Marina S., et al.
Publicado: (2013)

Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life
por: Davies, Elizabeth R., et al.
Publicado: (2016)

Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3–like protein 1
por: Hinks, Timothy S.C., et al.
Publicado: (2016)

Immunological characterisation of an acute murine model of lung inflammation and airway hyperreactivity
por: Dixon, Kate L, et al.
Publicado: (2013)

Peripheral airways involvement in children with asthma exacerbation
por: Wawszczak, Maria, et al.
Publicado: (2021)

The Role of Airway Epithelial Cell Alarmins in Asthma
por: Whetstone, Christiane E., et al.
Publicado: (2022)

Airway epithelial Paraoxonase-2 in obese asthma
por: Winnica, Daniel Efrain, et al.
Publicado: (2022)

Viral Infection and Airway Epithelial Immunity in Asthma
por: Kim, So Ri
Publicado: (2022)

Airway Epithelial Dysfunction in Asthma: Relevant to Epidermal Growth Factor Receptors and Airway Epithelial Cells
por: Inoue, Hideki, et al.
Publicado: (2020)

National roll-out of latent tuberculosis testing and treatment for new migrants in England: a retrospective evaluation in a high-incidence area
por: Loutet, Miranda G., et al.
Publicado: (2018)

Gender-Dependent Differences in Plasma Matrix Metalloproteinase-8 Elevated in Pulmonary Tuberculosis
por: Sathyamoorthy, Tarangini, et al.
Publicado: (2015)

Assessment of Peripheral Airway Function following Chronic Allergen Challenge in a Sheep Model of Asthma
por: Van der Velden, Joanne, et al.
Publicado: (2011)

A Study to Investigate the Prevalence of Device-Specific Errors in Inhaler Technique in Adults With Airway Disease (The SCORES Study): Protocol for a Single Visit Prevalence Study
por: De Vos, Ruth, et al.
Publicado: (2021)

A metric for evaluating biological information in gene sets and its application to identify co-expressed gene clusters in PBMC
por: Bennett, Jason, et al.
Publicado: (2021)

Role of airway epithelial cell miRNAs in asthma
por: Boateng, Eistine, et al.
Publicado: (2022)

Role of air pollutants in airway epithelial barrier dysfunction in asthma and COPD
por: Aghapour, Mahyar, et al.
Publicado: (2022)

Mechanisms of airway epithelial injury and abnormal repair in asthma and COPD
por: Raby, Katie Louise, et al.
Publicado: (2023)

Aberrant Epithelial Cell Proliferation in Peripheral Airways in Bronchiectasis
por: Peng, Yang, et al.
Publicado: (2020)

A new look at the pathogenesis of asthma
por: Holgate, Stephen T., et al.
Publicado: (2009)

Modern Innovative Solutions to Improve Outcomes in Asthma, Breathlessness, and Chronic Obstructive Pulmonary Disease (MISSION ABC): Protocol for a Mixed-Methods Study
por: Lanning, Eleanor, et al.
Publicado: (2019)

Effective Delivery of PEGylated siRNA-Containing Lipoplexes to Extraperitoneal Tumours following Intraperitoneal Administration
por: Singhania, Akul, et al.
Publicado: (2011)

Epithelial-interleukin-1 inhibits collagen formation by airway fibroblasts: Implications for asthma
por: Osei, Emmanuel T., et al.
Publicado: (2020)

Mechanical forces induce an asthma gene signature in healthy airway epithelial cells
por: Kılıç, Ayşe, et al.
Publicado: (2020)

Protocadherin-1 Localization and Cell-Adhesion Function in Airway Epithelial Cells in Asthma
por: Faura Tellez, Grissel, et al.
Publicado: (2016)

Alteration in Claudin-4 Contributes to Airway Inflammation and Responsiveness in Asthma
por: Lee, Pureun-Haneul, et al.
Publicado: (2018)

Airways exudation of plasma macromolecules: Innate defense, epithelial regeneration, and asthma
por: Persson, Carl
Publicado: (2019)

Epigenomic response to albuterol treatment in asthma-relevant airway epithelial cells
por: Perez-Garcia, Javier, et al.
Publicado: (2023)

12/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma
por: Mabalirajan, Ulaganathan, et al.
Publicado: (2013)

Blood eosinophil count and airway epithelial transcriptome relationships in COPD versus asthma
por: George, Leena, et al.
Publicado: (2019)

Detecting Alterations in Pulmonary Airway Development with Airway-by-Airway Comparison
por: Lee, DongYoub, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_qghjk8etcvhs4c7sbqb078uf9d