Cargando…
Single Cell Mathematical Model Successfully Replicates Key Features of GBM: Go-Or-Grow Is Not Necessary
Glioblastoma (GBM) is a malignant brain tumor that continues to be associated with neurological morbidity and poor survival times. Brain invasion is a fundamental property of malignant glioma cells. The Go-or-Grow (GoG) phenotype proposes that cancer cell motility and proliferation are mutually excl...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207515/ https://www.ncbi.nlm.nih.gov/pubmed/28046101 http://dx.doi.org/10.1371/journal.pone.0169434 |
_version_ | 1782490375994212352 |
---|---|
author | Scribner, Elizabeth Fathallah-Shaykh, Hassan M. |
author_facet | Scribner, Elizabeth Fathallah-Shaykh, Hassan M. |
author_sort | Scribner, Elizabeth |
collection | PubMed |
description | Glioblastoma (GBM) is a malignant brain tumor that continues to be associated with neurological morbidity and poor survival times. Brain invasion is a fundamental property of malignant glioma cells. The Go-or-Grow (GoG) phenotype proposes that cancer cell motility and proliferation are mutually exclusive. Here, we construct and apply a single glioma cell mathematical model that includes motility and angiogenesis and lacks the GoG phenotype. Simulations replicate key features of GBM including its multilayer structure (i.e.edema, enhancement, and necrosis), its progression patterns associated with bevacizumab treatment, and replicate the survival times of GBM treated or untreated with bevacizumab. These results suggest that the GoG phenotype is not a necessary property for the formation of the multilayer structure, recurrence patterns, and the poor survival times of patients diagnosed with GBM. |
format | Online Article Text |
id | pubmed-5207515 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-52075152017-01-19 Single Cell Mathematical Model Successfully Replicates Key Features of GBM: Go-Or-Grow Is Not Necessary Scribner, Elizabeth Fathallah-Shaykh, Hassan M. PLoS One Research Article Glioblastoma (GBM) is a malignant brain tumor that continues to be associated with neurological morbidity and poor survival times. Brain invasion is a fundamental property of malignant glioma cells. The Go-or-Grow (GoG) phenotype proposes that cancer cell motility and proliferation are mutually exclusive. Here, we construct and apply a single glioma cell mathematical model that includes motility and angiogenesis and lacks the GoG phenotype. Simulations replicate key features of GBM including its multilayer structure (i.e.edema, enhancement, and necrosis), its progression patterns associated with bevacizumab treatment, and replicate the survival times of GBM treated or untreated with bevacizumab. These results suggest that the GoG phenotype is not a necessary property for the formation of the multilayer structure, recurrence patterns, and the poor survival times of patients diagnosed with GBM. Public Library of Science 2017-01-03 /pmc/articles/PMC5207515/ /pubmed/28046101 http://dx.doi.org/10.1371/journal.pone.0169434 Text en © 2017 Scribner, Fathallah-Shaykh http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Scribner, Elizabeth Fathallah-Shaykh, Hassan M. Single Cell Mathematical Model Successfully Replicates Key Features of GBM: Go-Or-Grow Is Not Necessary |
title | Single Cell Mathematical Model Successfully Replicates Key Features of GBM: Go-Or-Grow Is Not Necessary |
title_full | Single Cell Mathematical Model Successfully Replicates Key Features of GBM: Go-Or-Grow Is Not Necessary |
title_fullStr | Single Cell Mathematical Model Successfully Replicates Key Features of GBM: Go-Or-Grow Is Not Necessary |
title_full_unstemmed | Single Cell Mathematical Model Successfully Replicates Key Features of GBM: Go-Or-Grow Is Not Necessary |
title_short | Single Cell Mathematical Model Successfully Replicates Key Features of GBM: Go-Or-Grow Is Not Necessary |
title_sort | single cell mathematical model successfully replicates key features of gbm: go-or-grow is not necessary |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207515/ https://www.ncbi.nlm.nih.gov/pubmed/28046101 http://dx.doi.org/10.1371/journal.pone.0169434 |
work_keys_str_mv | AT scribnerelizabeth singlecellmathematicalmodelsuccessfullyreplicateskeyfeaturesofgbmgoorgrowisnotnecessary AT fathallahshaykhhassanm singlecellmathematicalmodelsuccessfullyreplicateskeyfeaturesofgbmgoorgrowisnotnecessary |