Cargando…

An Experimental Analysis of the Molecular Effects of Trastuzumab (Herceptin) and Fulvestrant (Falsodex), as Single Agents or in Combination, on Human HR+/HER2+ Breast Cancer Cell Lines and Mouse Tumor Xenografts

PURPOSE: To investigate the effects of trastuzumab (herceptin) and fulvestrant (falsodex) either in combination or alone, on downstream cell signaling pathways in lab-cultured human HR+/HER2+ breast cancer cell lines ZR-75-1 and BT-474, as well as on protein expression levels in mouse xenograft tiss...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Qing, Weng, Ziyi, Lu, Yunshu, Jia, Yijun, Ding, Longlong, Bai, Fang, Ge, Meixin, Lin, Qing, Wu, Kejin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207527/
https://www.ncbi.nlm.nih.gov/pubmed/28045951
http://dx.doi.org/10.1371/journal.pone.0168960