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An Experimental Analysis of the Molecular Effects of Trastuzumab (Herceptin) and Fulvestrant (Falsodex), as Single Agents or in Combination, on Human HR+/HER2+ Breast Cancer Cell Lines and Mouse Tumor Xenografts

PURPOSE: To investigate the effects of trastuzumab (herceptin) and fulvestrant (falsodex) either in combination or alone, on downstream cell signaling pathways in lab-cultured human HR+/HER2+ breast cancer cell lines ZR-75-1 and BT-474, as well as on protein expression levels in mouse xenograft tiss...

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Detalles Bibliográficos
Autores principales:	Chen, Qing, Weng, Ziyi, Lu, Yunshu, Jia, Yijun, Ding, Longlong, Bai, Fang, Ge, Meixin, Lin, Qing, Wu, Kejin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207527/ https://www.ncbi.nlm.nih.gov/pubmed/28045951 http://dx.doi.org/10.1371/journal.pone.0168960

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