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Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy

Apigenin (4′,5,7-trihydroxyflavone) is a flavonoid commonly found in many fruits and vegetables such as parsley, chamomile, celery, and kumquats. In the last few decades, recognition of apigenin as a cancer chemopreventive agent has increased. Significant progress has been made in studying the chemo...

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Detalles Bibliográficos
Autores principales: Sung, Bokyung, Chung, Hae Young, Kim, Nam Deuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Cancer Prevention 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207605/
https://www.ncbi.nlm.nih.gov/pubmed/28053955
http://dx.doi.org/10.15430/JCP.2016.21.4.216
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author Sung, Bokyung
Chung, Hae Young
Kim, Nam Deuk
author_facet Sung, Bokyung
Chung, Hae Young
Kim, Nam Deuk
author_sort Sung, Bokyung
collection PubMed
description Apigenin (4′,5,7-trihydroxyflavone) is a flavonoid commonly found in many fruits and vegetables such as parsley, chamomile, celery, and kumquats. In the last few decades, recognition of apigenin as a cancer chemopreventive agent has increased. Significant progress has been made in studying the chemopreventive aspects of apigenin both in vitro and in vivo. Several studies have demonstrated that the anticarcinogenic properties of apigenin occur through regulation of cellular response to oxidative stress and DNA damage, suppression of inflammation and angiogenesis, retardation of cell proliferation, and induction of autophagy and apoptosis. One of the most well-recognized mechanisms of apigenin is the capability to promote cell cycle arrest and induction of apoptosis through the p53-related pathway. A further role of apigenin in chemoprevention is the induction of autophagy in several human cancer cell lines. In this review, we discuss the details of apigenin, apoptosis, autophagy, and the role of apigenin in cancer chemoprevention via the induction of apoptosis and autophagy.
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spelling pubmed-52076052017-01-04 Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy Sung, Bokyung Chung, Hae Young Kim, Nam Deuk J Cancer Prev Review Apigenin (4′,5,7-trihydroxyflavone) is a flavonoid commonly found in many fruits and vegetables such as parsley, chamomile, celery, and kumquats. In the last few decades, recognition of apigenin as a cancer chemopreventive agent has increased. Significant progress has been made in studying the chemopreventive aspects of apigenin both in vitro and in vivo. Several studies have demonstrated that the anticarcinogenic properties of apigenin occur through regulation of cellular response to oxidative stress and DNA damage, suppression of inflammation and angiogenesis, retardation of cell proliferation, and induction of autophagy and apoptosis. One of the most well-recognized mechanisms of apigenin is the capability to promote cell cycle arrest and induction of apoptosis through the p53-related pathway. A further role of apigenin in chemoprevention is the induction of autophagy in several human cancer cell lines. In this review, we discuss the details of apigenin, apoptosis, autophagy, and the role of apigenin in cancer chemoprevention via the induction of apoptosis and autophagy. Korean Society of Cancer Prevention 2016-12 2016-12-30 /pmc/articles/PMC5207605/ /pubmed/28053955 http://dx.doi.org/10.15430/JCP.2016.21.4.216 Text en Copyright © 2016 Korean Society of Cancer Prevention This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Sung, Bokyung
Chung, Hae Young
Kim, Nam Deuk
Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy
title Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy
title_full Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy
title_fullStr Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy
title_full_unstemmed Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy
title_short Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy
title_sort role of apigenin in cancer prevention via the induction of apoptosis and autophagy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207605/
https://www.ncbi.nlm.nih.gov/pubmed/28053955
http://dx.doi.org/10.15430/JCP.2016.21.4.216
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