Implications of the differing roles of the β1 and β3 transmembrane and cytoplasmic domains for integrin function

Integrins are transmembrane receptors composed of α and β subunits. Although most integrins contain β1, canonical activation mechanisms are based on studies of the platelet integrin, αIIbβ3. Its inactive conformation is characterized by the association of the αIIb transmembrane and cytosolic domain...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Zhenwei, Mathew, Sijo, Chen, Jiang, Hadziselimovic, Arina, Palamuttam, Riya, Hudson, Billy G, Fässler, Reinhard, Pozzi, Ambra, Sanders, Charles R, Zent, Roy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207772/
https://www.ncbi.nlm.nih.gov/pubmed/27929375
http://dx.doi.org/10.7554/eLife.18633

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207772/
https://www.ncbi.nlm.nih.gov/pubmed/27929375
http://dx.doi.org/10.7554/eLife.18633

Ejemplares similares