Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity

hIAPP fibrils are associated with Type-II Diabetes, but the link of hIAPP structure to islet cell death remains elusive. Here we observe that hIAPP fibrils are cytotoxic to cultured pancreatic β-cells, leading us to determine the structure and cytotoxicity of protein segments composing the amyloid s...

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Detalles Bibliográficos
Autores principales: Krotee, Pascal, Rodriguez, Jose A, Sawaya, Michael R, Cascio, Duilio, Reyes, Francis E, Shi, Dan, Hattne, Johan, Nannenga, Brent L, Oskarsson, Marie E, Philipp, Stephan, Griner, Sarah, Jiang, Lin, Glabe, Charles G, Westermark, Gunilla T, Gonen, Tamir, Eisenberg, David S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207774/
https://www.ncbi.nlm.nih.gov/pubmed/28045370
http://dx.doi.org/10.7554/eLife.19273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207774/
https://www.ncbi.nlm.nih.gov/pubmed/28045370
http://dx.doi.org/10.7554/eLife.19273

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