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Permeation Mechanisms in the TMEM16B Calcium-Activated Chloride Channels
TMEM16A and TMEM16B encode for Ca(2+)-activated Cl(−) channels (CaCC) and are expressed in many cell types and play a relevant role in many physiological processes. Here, I performed a site-directed mutagenesis study to understand the molecular mechanisms of ion permeation of TMEM16B. I mutated two...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207786/ https://www.ncbi.nlm.nih.gov/pubmed/28046119 http://dx.doi.org/10.1371/journal.pone.0169572 |