Intracerebral Administration of S-Adenosylhomocysteine or S-Adenosylmethionine Attenuates the Increases in the Cortical Extracellular Levels of Dimethylarginines Without Affecting cGMP Level in Rats with Acute Liver Failure

Alterations in brain nitric oxide (NO)/cGMP synthesis contribute to the pathogenesis of hepatic encephalopathy (HE). An increased asymmetrically dimethylated derivative of l-arginine (ADMA), an endogenous inhibitor of NO synthases, was observed in plasma of HE patients and animal models. It is not c...

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Detalles Bibliográficos
Autores principales: Czarnecka, Anna, Milewski, Krzysztof, Jaźwiec, Radosław, Zielińska, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209417/
https://www.ncbi.nlm.nih.gov/pubmed/27604291
http://dx.doi.org/10.1007/s12640-016-9668-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209417/
https://www.ncbi.nlm.nih.gov/pubmed/27604291
http://dx.doi.org/10.1007/s12640-016-9668-7

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