Intercalative DNA binding of the marine anticancer drug variolin B

Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic effects is still unknown. The crystal structure of a variolin B bound to a DN...

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Detalles Bibliográficos
Autores principales: Canals, Albert, Arribas-Bosacoma, Raquel, Albericio, Fernando, Álvarez, Mercedes, Aymamí, Joan, Coll, Miquel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209663/
https://www.ncbi.nlm.nih.gov/pubmed/28051169
http://dx.doi.org/10.1038/srep39680

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209663/
https://www.ncbi.nlm.nih.gov/pubmed/28051169
http://dx.doi.org/10.1038/srep39680

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