Intercalative DNA binding of the marine anticancer drug variolin B

Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic effects is still unknown. The crystal structure of a variolin B bound to a DN...

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Autores principales: Canals, Albert, Arribas-Bosacoma, Raquel, Albericio, Fernando, Álvarez, Mercedes, Aymamí, Joan, Coll, Miquel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209663/
https://www.ncbi.nlm.nih.gov/pubmed/28051169
http://dx.doi.org/10.1038/srep39680
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author Canals, Albert
Arribas-Bosacoma, Raquel
Albericio, Fernando
Álvarez, Mercedes
Aymamí, Joan
Coll, Miquel
author_facet Canals, Albert
Arribas-Bosacoma, Raquel
Albericio, Fernando
Álvarez, Mercedes
Aymamí, Joan
Coll, Miquel
author_sort Canals, Albert
collection PubMed
description Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic effects is still unknown. The crystal structure of a variolin B bound to a DNA forming a pseudo-Holliday junction shows that this compound can also contribute, through intercalative binding, to either the formation or stabilization of multi-stranded DNA forms.
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spelling pubmed-52096632017-01-04 Intercalative DNA binding of the marine anticancer drug variolin B Canals, Albert Arribas-Bosacoma, Raquel Albericio, Fernando Álvarez, Mercedes Aymamí, Joan Coll, Miquel Sci Rep Article Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic effects is still unknown. The crystal structure of a variolin B bound to a DNA forming a pseudo-Holliday junction shows that this compound can also contribute, through intercalative binding, to either the formation or stabilization of multi-stranded DNA forms. Nature Publishing Group 2017-01-04 /pmc/articles/PMC5209663/ /pubmed/28051169 http://dx.doi.org/10.1038/srep39680 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Canals, Albert
Arribas-Bosacoma, Raquel
Albericio, Fernando
Álvarez, Mercedes
Aymamí, Joan
Coll, Miquel
Intercalative DNA binding of the marine anticancer drug variolin B
title Intercalative DNA binding of the marine anticancer drug variolin B
title_full Intercalative DNA binding of the marine anticancer drug variolin B
title_fullStr Intercalative DNA binding of the marine anticancer drug variolin B
title_full_unstemmed Intercalative DNA binding of the marine anticancer drug variolin B
title_short Intercalative DNA binding of the marine anticancer drug variolin B
title_sort intercalative dna binding of the marine anticancer drug variolin b
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209663/
https://www.ncbi.nlm.nih.gov/pubmed/28051169
http://dx.doi.org/10.1038/srep39680
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