HIV-1 Env associates with HLA-C free-chains at the cell membrane modulating viral infectivity

HLA-C has been demonstrated to associate with HIV-1 envelope glycoprotein (Env). Virions lacking HLA-C have reduced infectivity and increased susceptibility to neutralizing antibodies. Like all others MHC-I molecules, HLA-C requires β(2)-microglobulin (β(2)m) for appropriate folding and expression o...

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Detalles Bibliográficos
Autores principales: Serena, Michela, Parolini, Francesca, Biswas, Priscilla, Sironi, Francesca, Blanco Miranda, Almudena, Zoratti, Elisa, Scupoli, Maria Teresa, Ziglio, Serena, Valenzuela-Fernandez, Agustin, Gibellini, Davide, Romanelli, Maria Grazia, Siccardi, Antonio, Malnati, Mauro, Beretta, Alberto, Zipeto, Donato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209703/
https://www.ncbi.nlm.nih.gov/pubmed/28051183
http://dx.doi.org/10.1038/srep40037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209703/
https://www.ncbi.nlm.nih.gov/pubmed/28051183
http://dx.doi.org/10.1038/srep40037

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