Detecting very low allele fraction variants using targeted DNA sequencing and a novel molecular barcode-aware variant caller

BACKGROUND: Detection of DNA mutations at very low allele fractions with high accuracy will significantly improve the effectiveness of precision medicine for cancer patients. To achieve this goal through next generation sequencing, researchers need a detection method that 1) captures rare mutation-c...

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Detalles Bibliográficos
Autores principales: Xu, Chang, Nezami Ranjbar, Mohammad R., Wu, Zhong, DiCarlo, John, Wang, Yexun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209917/
https://www.ncbi.nlm.nih.gov/pubmed/28049435
http://dx.doi.org/10.1186/s12864-016-3425-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209917/
https://www.ncbi.nlm.nih.gov/pubmed/28049435
http://dx.doi.org/10.1186/s12864-016-3425-4

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