Impaired liver regeneration in aged mice can be rescued by silencing Hippo core kinases MST1 and MST2

The liver has an intrinsic capacity to regenerate in response to injury or surgical resection. Nevertheless, circumstances in which hepatocytes are unresponsive to proliferative signals result in impaired regeneration and hepatic failure. As the Hippo pathway has a canonical role in the maintenance...

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Detalles Bibliográficos
Autores principales: Loforese, Giulio, Malinka, Thomas, Keogh, Adrian, Baier, Felix, Simillion, Cedric, Montani, Matteo, Halazonetis, Thanos D, Candinas, Daniel, Stroka, Deborah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210079/
https://www.ncbi.nlm.nih.gov/pubmed/27940445
http://dx.doi.org/10.15252/emmm.201506089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210079/
https://www.ncbi.nlm.nih.gov/pubmed/27940445
http://dx.doi.org/10.15252/emmm.201506089

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