Contrasting Nav1.8 Activity in Scn10a (−/−) Ventricular Myocytes and the Intact Heart

BACKGROUND: Genome‐wide association studies have implicated variants in SCN10A, which encodes Nav1.8, as modulators of cardiac conduction. Follow‐up work has indicated the SCN10A sequence includes an intronic enhancer for SCN5A. Yet the role of the Nav1.8 protein in the myocardium itself is still un...

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Detalles Bibliográficos
Autores principales: Stroud, Dina Myers, Yang, Tao, Bersell, Kevin, Kryshtal, Dymtro O., Nagao, Satomi, Shaffer, Christian, Short, Laura, Hall, Lynn, Atack, Thomas C., Zhang, Wei, Knollmann, Bjorn C., Baudenbacher, Franz, Roden, Dan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210363/
https://www.ncbi.nlm.nih.gov/pubmed/27806966
http://dx.doi.org/10.1161/JAHA.115.002946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210363/
https://www.ncbi.nlm.nih.gov/pubmed/27806966
http://dx.doi.org/10.1161/JAHA.115.002946

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