Cargando…

miR‐17/20 Controls Prolyl Hydroxylase 2 (PHD2)/Hypoxia‐Inducible Factor 1 (HIF1) to Regulate Pulmonary Artery Smooth Muscle Cell Proliferation

BACKGROUND: Previously we found that smooth muscle cell (SMC)‐specific knockout of miR‐17~92 attenuates hypoxia‐induced pulmonary hypertension. However, the mechanism underlying miR‐17~92‐mediated pulmonary artery SMC (PASMC) proliferation remains unclear. We sought to investigate whether miR‐17~92...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Tianji, Zhou, Qiyuan, Tang, Haiyang, Bozkanat, Melike, Yuan, Jason X.‐J., Raj, J. Usha, Zhou, Guofei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210422/
https://www.ncbi.nlm.nih.gov/pubmed/27919930
http://dx.doi.org/10.1161/JAHA.116.004510