CREB overexpression in dorsal CA1 ameliorates long-term memory deficits in aged rats

The molecular mechanisms underlying age-related cognitive deficits are not yet fully elucidated. In aged animals, a decrease in the intrinsic excitability of CA1 pyramidal neurons is believed to contribute to age-related cognitive impairments. Increasing activity of the transcription factor cAMP res...

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Detalles Bibliográficos
Autores principales: Yu, Xiao-Wen, Curlik, Daniel M, Oh, M Matthew, Yin, Jerry CP, Disterhoft, John F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214885/
https://www.ncbi.nlm.nih.gov/pubmed/28051768
http://dx.doi.org/10.7554/eLife.19358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214885/
https://www.ncbi.nlm.nih.gov/pubmed/28051768
http://dx.doi.org/10.7554/eLife.19358

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