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Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signals

Inflammation is the host response to microbial infection or sterile injury that aims to eliminate the insult, repair the tissue and restore homeostasis. Macrophages and the NLRP3 inflammasome are key sentinels for both types of insult. Although it is well established that the NLRP3 inflammasome is a...

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Detalles Bibliográficos
Autores principales: Bezbradica, Jelena S, Coll, Rebecca C, Schroder, Kate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214936/
https://www.ncbi.nlm.nih.gov/pubmed/26996064
http://dx.doi.org/10.1038/cmi.2016.11