JNK activation is essential for activation of MEK/ERK signaling in IL-1β-induced COX-2 expression in synovial fibroblasts

The proinflammatory cytokine interleukin 1β (IL-1β) induces prostaglandin E(2) (PGE(2)) production via upregulation of cyclooxygenase-2 (COX-2) expression in synovial fibroblasts. This effect of IL-1β is involved in osteoarthritis. We investigated MAPK signaling pathways in IL-1β-induced COX-2 expre...

Descripción completa

Detalles Bibliográficos
Autores principales: Kitanaka, Taku, Nakano, Rei, Kitanaka, Nanako, Kimura, Taro, Okabayashi, Ken, Narita, Takanori, Sugiya, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215076/
https://www.ncbi.nlm.nih.gov/pubmed/28054591
http://dx.doi.org/10.1038/srep39914

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215076/
https://www.ncbi.nlm.nih.gov/pubmed/28054591
http://dx.doi.org/10.1038/srep39914

Ejemplares similares