CD8(+) T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold

The CD8 co-receptor engages peptide-major histocompatibility complex class I (pMHCI) molecules at a largely invariant site distinct from the T-cell receptor (TCR)-binding platform and enhances the sensitivity of antigen-driven activation to promote effective CD8(+) T-cell immunity. A small increase...

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Detalles Bibliográficos
Autores principales: Dockree, Tamsin, Holland, Christopher J, Clement, Mathew, Ladell, Kristin, McLaren, James E, van den Berg, Hugo A, Gostick, Emma, L Miners, Kelly, Llewellyn-Lacey, Sian, Bridgeman, John S, Man, Stephen, Bailey, Mick, Burrows, Scott R, Price, David A, Wooldridge, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215125/
https://www.ncbi.nlm.nih.gov/pubmed/27670790
http://dx.doi.org/10.1038/icb.2016.85

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215125/
https://www.ncbi.nlm.nih.gov/pubmed/27670790
http://dx.doi.org/10.1038/icb.2016.85

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