Cargando…

CD8(+) T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold

The CD8 co-receptor engages peptide-major histocompatibility complex class I (pMHCI) molecules at a largely invariant site distinct from the T-cell receptor (TCR)-binding platform and enhances the sensitivity of antigen-driven activation to promote effective CD8(+) T-cell immunity. A small increase...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dockree, Tamsin, Holland, Christopher J, Clement, Mathew, Ladell, Kristin, McLaren, James E, van den Berg, Hugo A, Gostick, Emma, L Miners, Kelly, Llewellyn-Lacey, Sian, Bridgeman, John S, Man, Stephen, Bailey, Mick, Burrows, Scott R, Price, David A, Wooldridge, Linda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215125/ https://www.ncbi.nlm.nih.gov/pubmed/27670790 http://dx.doi.org/10.1038/icb.2016.85

Ejemplares similares

High-affinity CD8 variants enhance the sensitivity of pMHCI antigen recognition via low-affinity TCRs
por: Knezevic, Lea, et al.
Publicado: (2023)

CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor
por: Clement, Mathew, et al.
Publicado: (2021)

Targeted suppression of autoreactive CD8(+) T-cell activation using blocking anti-CD8 antibodies
por: Clement, Mathew, et al.
Publicado: (2016)

Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8(+) TCR-Vβ(+) expansions
por: Lissina, Anna, et al.
Publicado: (2018)

Avidity of influenza-specific memory CD8(+) T-cell populations decays over time compromising antiviral immunity
por: Humphreys, Ian R, et al.
Publicado: (2012)

Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141(+) dendritic cells to activate naïve and memory WT1‐specific CD8(+) T cells
por: Pearson, Frances E, et al.
Publicado: (2020)

Naive CD8(+) T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics
por: Neller, Michelle A, et al.
Publicado: (2015)

Cellular-Level Versus Receptor-Level Response Threshold Hierarchies in T-Cell Activation
por: van den Berg, Hugo A., et al.
Publicado: (2013)

Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors
por: Szomolay, Barbara, et al.
Publicado: (2016)

T cell receptor binding affinity governs the functional profile of cancer-specific CD8(+) T cells
por: Tan, M P, et al.
Publicado: (2015)

Integrin triplets of marine sponges in the murine and human MHCI-CD8 interface and in the interface of human neural receptor heteromers and subunits
por: Tarakanov, Alexander O, et al.
Publicado: (2013)

Individual MHCI-Restricted T-Cell Receptors are Characterized by a Unique Peptide Recognition Signature
por: Wooldridge, Linda
Publicado: (2013)

Proinsulin Expression Shapes the TCR Repertoire but Fails to Control the Development of Low-Avidity Insulin-Reactive CD8(+) T Cells
por: Pearson, James A., et al.
Publicado: (2016)

Counteracting roles of MHCI and CD8(+) T cells in the peripheral and central nervous system of ALS SOD1(G93A) mice
por: Nardo, Giovanni, et al.
Publicado: (2018)

TOX defines the degree of CD8+ T cell dysfunction in distinct phases of chronic HBV infection
por: Heim, Kathrin, et al.
Publicado: (2021)

Co-Receptor CD8-Mediated Modulation of T-Cell Receptor Functional Sensitivity and Epitope Recognition Degeneracy
por: Szomolay, Barbara, et al.
Publicado: (2013)

The superantigens SpeC and TSST-1 specifically activate TRBV12-3/12-4(+) memory T cells
por: Shepherd, Freya R., et al.
Publicado: (2023)

IL-33 Augments Virus-Specific Memory T Cell Inflation and Potentiates the Efficacy of an Attenuated Cytomegalovirus-Based Vaccine
por: McLaren, James E., et al.
Publicado: (2019)

CD8(+) memory T-cell inflation renders compromised CD4(+) T-cell-dependent CD8(+) T-cell immunity via naïve T-cell anergy
por: Xu, Aizhang, et al.
Publicado: (2017)

Corrigendum: Co-Receptor CD8-Mediated Modulation of T-Cell Receptor Functional Sensitivity and Epitope Recognition Degeneracy
por: Szomolay, Barbara, et al.
Publicado: (2014)

Altered basal lipid metabolism underlies the functional impairment of naive CD8(+) T cells in elderly humans
por: Nicoli, Francesco, et al.
Publicado: (2022)

CD8(+) T Cell Immunity Is Compromised by Anti-CD20 Treatment and Rescued by Interleukin-17A
por: Fiocca Vernengo, Facundo, et al.
Publicado: (2020)

CD3ζ-based chimeric antigen receptors mediate T cell activation via cis- and trans-signalling mechanisms: implications for optimization of receptor structure for adoptive cell therapy
por: Bridgeman, J S, et al.
Publicado: (2014)

Two subsets of stem-like CD8(+) memory T cell progenitors with distinct fate commitments in humans
por: Galletti, Giovanni, et al.
Publicado: (2020)

Selective inhibition of low-affinity memory CD8(+) T cells by corticosteroids
por: Tokunaga, Akihiro, et al.
Publicado: (2019)

Purity of transferred CD8(+) T cells is crucial for safety and efficacy of combinatorial tumor immunotherapy in the absence of SHP-1
por: Watson, H Angharad, et al.
Publicado: (2016)

Inefficient induction of circulating TAA-specific CD8+ T-cell responses in hepatocellular carcinoma
por: Tauber, Catrin, et al.
Publicado: (2019)

Naïve CD8(+) T-Cells Engage a Versatile Metabolic Program Upon Activation in Humans and Differ Energetically From Memory CD8(+) T-Cells
por: Nicoli, Francesco, et al.
Publicado: (2018)

DeepMHCI: an anchor position-aware deep interaction model for accurate MHC-I peptide binding affinity prediction
por: Qu, Wei, et al.
Publicado: (2023)

Avidity for antigen shapes clonal dominance in CD8(+) T cell populations specific for persistent DNA viruses
por: Price, David A., et al.
Publicado: (2005)

Cytomegalovirus-specific CD8 T cells kill B16 melanoma cells in vivo when activated by bifunctional major histocompatibility class I - antibody fusion molecules (pMHCI-IgGs).
por: Munks, Michael, et al.
Publicado: (2015)

Ageing Curtails the Diversity and Functionality of Nascent CD8(+) T Cell Responses against SARS-CoV-2
por: Proietto, Davide, et al.
Publicado: (2023)

Compromised CD4:CD8 ratio recovery in people living with HIV aged over 50 years: an observational study
por: Francis‐Morris, A, et al.
Publicado: (2019)

Early Priming Minimizes the Age-Related Immune Compromise of CD8(+) T Cell Diversity and Function
por: Valkenburg, Sophie A., et al.
Publicado: (2012)

Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region
por: Wooldridge, Linda, et al.
Publicado: (2007)

TRAV1-2(+) CD8(+) T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis
por: Wong, Emily B., et al.
Publicado: (2019)

Programmed death-1 expression on HIV-1-specific CD8(+) T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load
por: Kløverpris, Henrik N., et al.
Publicado: (2014)

Analysis of the functional WT1-specific T-cell repertoire in healthy donors reveals a discrepancy between CD4(+) and CD8(+) memory formation
por: Schmied, Sabine, et al.
Publicado: (2015)

CD8 is required during positive selection of CD4-/CD8+ T cells
Publicado: (1990)

Regulation of CD4(+)CD8(−)CD25(+) and CD4(+)CD8(+)CD25(+) T cells by gut microbiota in chicken
por: Lee, In Kyu, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_420j5bg6307vdo1604tivgnhua