Cargando…
Concerted action of the MutLβ heterodimer and Mer3 helicase regulates the global extent of meiotic gene conversion
Gene conversions resulting from meiotic recombination are critical in shaping genome diversification and evolution. How the extent of gene conversions is regulated is unknown. Here we show that the budding yeast mismatch repair related MutLβ complex, Mlh1-Mlh2, specifically interacts with the conser...
Autores principales: | Duroc, Yann, Kumar, Rajeev, Ranjha, Lepakshi, Adam, Céline, Guérois, Raphaël, Md Muntaz, Khan, Marsolier-Kergoat, Marie-Claude, Dingli, Florent, Laureau, Raphaëlle, Loew, Damarys, Llorente, Bertrand, Charbonnier, Jean-Baptiste, Cejka, Petr, Borde, Valérie |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215242/ https://www.ncbi.nlm.nih.gov/pubmed/28051769 http://dx.doi.org/10.7554/eLife.21900 |
Ejemplares similares
-
The Pif1 helicase is actively inhibited during meiotic recombination which restrains gene conversion tract length
por: Vernekar, Dipti Vinayak, et al.
Publicado: (2021) -
MutLα Heterodimers Modify the Molecular Phenotype of Friedreich Ataxia
por: Ezzatizadeh, Vahid, et al.
Publicado: (2014) -
A meiotic XPF–ERCC1-like complex recognizes joint molecule recombination intermediates to promote crossover formation
por: De Muyt, Arnaud, et al.
Publicado: (2018) -
MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA
por: Groothuizen, Flora S, et al.
Publicado: (2015) -
PCNA activates the MutLγ endonuclease to promote meiotic crossing over
por: Kulkarni, Dhananjaya S., et al.
Publicado: (2020)