Cargando…

CD36/Sirtuin 1 Axis Impairment Contributes to Hepatic Steatosis in ACE2-Deficient Mice

Background and Aims. Angiotensin converting enzyme 2 (ACE2) is an important component of the renin-angiotensin system. Since angiotensin peptides have been shown to be involved in hepatic steatosis, we aimed to evaluate the hepatic lipid profile in ACE2-deficient (ACE2(−/y)) mice. Methods. Male C57B...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nunes-Souza, Valéria, Alenina, Natalia, Qadri, Fatimunnisa, Penninger, Josef M., Santos, Robson Augusto S., Bader, Michael, Rabelo, Luiza A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215286/ https://www.ncbi.nlm.nih.gov/pubmed/28101297 http://dx.doi.org/10.1155/2016/6487509

Ejemplares similares

Genetic Deletion of ACE2 Induces Vascular Dysfunction in C57BL/6 Mice: Role of Nitric Oxide Imbalance and Oxidative Stress
por: Rabelo, Luiza A., et al.
Publicado: (2016)

Animal Models with a Genetic Alteration of the ACE2/Ang-(1-7)/Mas Axis
por: Rabelo, Luiza A., et al.
Publicado: (2015)

Angiotensin-(1–7) Receptor Mas Deficiency Does Not Exacerbate Cardiac Atrophy Following High-Level Spinal Cord Injury in Mice
por: Järve, Anne, et al.
Publicado: (2020)

Glucagon-producing cells are increased in Mas-deficient mice
por: Felix Braga, Janaína, et al.
Publicado: (2016)

ACE2 in Brain Physiology and Pathophysiology: Evidence from Transgenic Animal Models
por: Alenina, Natalia, et al.
Publicado: (2018)

Anti-inflammatory role of Gpnmb in adipose tissue of mice
por: Nickl, Bernadette, et al.
Publicado: (2021)

Ochratoxin A Induces Steatosis via PPARγ-CD36 Axis
por: Zheng, Qian-Wen, et al.
Publicado: (2021)

3-Amino-1,2,4-Triazole Induces Quick and Strong Fat Loss in Mice with High Fat-Induced Metabolic Syndrome
por: Nunes-Souza, Valéria, et al.
Publicado: (2020)

Kpna6 deficiency causes infertility in male mice by disrupting spermatogenesis
por: Liu, Na, et al.
Publicado: (2021)

Depletion of angiotensin-converting enzyme 2 reduces brain serotonin and impairs the running-induced neurogenic response
por: Klempin, Friederike, et al.
Publicado: (2018)

ACE2 – From the renin–angiotensin system to gut microbiota and malnutrition
por: Perlot, Thomas, et al.
Publicado: (2013)

Angiotensin-(1-7) and Mas: A Brief History
por: Alenina, Natalia, et al.
Publicado: (2015)

Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity
por: Batlle, Daniel, et al.
Publicado: (2022)

Angiotensin-Converting Enzyme 2 (ACE2) in the Pathogenesis of ARDS in COVID-19
por: Kuba, Keiji, et al.
Publicado: (2021)

Nephropathy in Hypertensive Animals Is Linked to M2 Macrophages and Increased Expression of the YM1/Chi3l3 Protein
por: Cavalcante, Paula Andréa Malveira, et al.
Publicado: (2019)

Ipragliflozin-induced improvement of liver steatosis in obese mice may involve sirtuin signaling
por: Suga, Takayoshi, et al.
Publicado: (2020)

Hypothalamic NAD(+)-Sirtuin Axis: Function and Regulation
por: Roh, Eun, et al.
Publicado: (2020)

Oxidative Status Imbalance in Patients with Metabolic Syndrome: Role of the Myeloperoxidase/Hydrogen Peroxide Axis
por: da Fonseca, Lucas José Sá, et al.
Publicado: (2014)

Hepatic DKK1-driven steatosis is CD36 dependent
por: Yang, Zhen, et al.
Publicado: (2022)

Deacetylation of XBP1s by sirtuin 6 confers resistance to ER stress-induced hepatic steatosis
por: Bang, In Hyuk, et al.
Publicado: (2019)

Lessons from SARS: control of acute lung failure by the SARS receptor ACE2
por: Kuba, Keiji, et al.
Publicado: (2006)

Increased vascular sympathetic modulation in mice with Mas receptor deficiency
por: Rabello Casali, Karina, et al.
Publicado: (2016)

Sirtuin 2 Prevents Liver Steatosis and Metabolic Disorders by Deacetylation of Hepatocyte Nuclear Factor 4α
por: Ren, Huihui, et al.
Publicado: (2021)

ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity
por: Patel, Vaibhav B., et al.
Publicado: (2016)

ACE2 Deficiency Enhances Angiotensin II-Mediated Aortic Profilin-1 Expression, Inflammation and Peroxynitrite Production
por: Jin, Hai-Yan, et al.
Publicado: (2012)

Alterations in mitochondrial dynamics with age‐related Sirtuin1/Sirtuin3 deficiency impair cardiomyocyte contractility
por: Zhang, Jingwen, et al.
Publicado: (2021)

Exaggerated aggression and decreased anxiety in mice deficient in brain serotonin
por: Mosienko, V, et al.
Publicado: (2012)

Alterations of sirtuins in mitochondrial cytochrome c-oxidase deficiency
por: Potthast, Arne Björn, et al.
Publicado: (2017)

Cardiovascular magnetic resonance detects microvascular dysfunction in a mouse model of hypertrophic cardiomyopathy
por: Ku, Min-Chi, et al.
Publicado: (2021)

Cathelicidin suppresses lipid accumulation and hepatic steatosis by inhibition of the CD36 receptor
por: Tran, Deanna Hoang-Yen, et al.
Publicado: (2016)

Trilogy of ACE2: A peptidase in the renin–angiotensin system, a SARS receptor, and a partner for amino acid transporters
por: Kuba, Keiji, et al.
Publicado: (2010)

Targeting the RANKL/RANK/OPG Axis for Cancer Therapy
por: Ming, Jie, et al.
Publicado: (2020)

Ethanol deprivation and central 5-HT deficiency differentially affect the mRNA editing of the 5-HT(2C) receptor in the mouse brain
por: Zaniewska, Magdalena, et al.
Publicado: (2023)

Kinin receptors regulate skeletal muscle regeneration: differential effects for B1 and B2 receptors
por: Martins, Leonardo, et al.
Publicado: (2023)

Sirtuin 6 Regulates the Activation of the ATP/Purinergic Axis in Endothelial Cells
por: Astigiano, Cecilia, et al.
Publicado: (2023)

Impaired mitochondrial medium-chain fatty acid oxidation drives periportal macrovesicular steatosis in sirtuin-5 knockout mice
por: Goetzman, Eric S., et al.
Publicado: (2020)

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target
por: Zhang, Haibo, et al.
Publicado: (2020)

In Vivo Renin Activity Imaging in the Kidney of Progeroid Ercc1 Mutant Mice
por: van Thiel, Bibi S., et al.
Publicado: (2021)

Sirtuin 3 deficiency does not impede digit regeneration in mice
por: Busse, Emily, et al.
Publicado: (2019)

Sirtuin 3 deficiency exacerbates age‐related periodontal disease
por: Chen, Junsheng, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_eqldge8im34k5m710sohvjvp3n