Blockade of sigma 1 receptors alleviates sensory signs of diabetic neuropathy in rats

BACKGROUND: E‐52862 (S1RA, 4‐[2‐[[5‐methyl‐1‐(2‐naphthalenyl)‐1H‐pyrazol‐3‐yl]oxy]ethyl]‐morpholine), a novel selective sigma 1 receptor (σ1R) antagonist, has demonstrated efficacy in nociceptive and neuropathic pain models. Our aim was to test if σ1R blockade with E‐52862 may modify the signs of ne...

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Detalles Bibliográficos
Autores principales: Paniagua, N., Girón, R., Goicoechea, C., López‐Miranda, V., Vela, J.M., Merlos, M., Martín Fontelles, M.I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215451/
https://www.ncbi.nlm.nih.gov/pubmed/27341510
http://dx.doi.org/10.1002/ejp.897

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215451/
https://www.ncbi.nlm.nih.gov/pubmed/27341510
http://dx.doi.org/10.1002/ejp.897

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