Human tau increases amyloid β plaque size but not amyloid β‐mediated synapse loss in a novel mouse model of Alzheimer's disease

Alzheimer's disease is characterized by the presence of aggregates of amyloid beta (Aβ) in senile plaques and tau in neurofibrillary tangles, as well as marked neuron and synapse loss. Of these pathological changes, synapse loss correlates most strongly with cognitive decline. Synapse loss occu...

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Detalles Bibliográficos
Autores principales: Jackson, Rosemary J., Rudinskiy, Nikita, Herrmann, Abigail G., Croft, Shaun, Kim, JeeSoo Monica, Petrova, Veselina, Ramos‐Rodriguez, Juan Jose, Pitstick, Rose, Wegmann, Susanne, Garcia‐Alloza, Monica, Carlson, George A., Hyman, Bradley T., Spires‐Jones, Tara L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Molecular and Synaptic Mechanisms
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215483/
https://www.ncbi.nlm.nih.gov/pubmed/27748574
http://dx.doi.org/10.1111/ejn.13442

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215483/
https://www.ncbi.nlm.nih.gov/pubmed/27748574
http://dx.doi.org/10.1111/ejn.13442

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