Cargando…

Human tau increases amyloid β plaque size but not amyloid β‐mediated synapse loss in a novel mouse model of Alzheimer's disease

Alzheimer's disease is characterized by the presence of aggregates of amyloid beta (Aβ) in senile plaques and tau in neurofibrillary tangles, as well as marked neuron and synapse loss. Of these pathological changes, synapse loss correlates most strongly with cognitive decline. Synapse loss occu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jackson, Rosemary J., Rudinskiy, Nikita, Herrmann, Abigail G., Croft, Shaun, Kim, JeeSoo Monica, Petrova, Veselina, Ramos‐Rodriguez, Juan Jose, Pitstick, Rose, Wegmann, Susanne, Garcia‐Alloza, Monica, Carlson, George A., Hyman, Bradley T., Spires‐Jones, Tara L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Molecular and Synaptic Mechanisms
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215483/ https://www.ncbi.nlm.nih.gov/pubmed/27748574 http://dx.doi.org/10.1111/ejn.13442

Ejemplares similares

Myelinated, synapsing cultures of murine spinal cord – validation as an in vitro model of the central nervous system
por: Thomson, C E, et al.
Publicado: (2008)

GABA(A) receptors can initiate the formation of functional inhibitory GABAergic synapses
por: Fuchs, Celine, et al.
Publicado: (2013)

Exploiting the molecular diversity of the synapse to investigate neuronal communication: A guide through the current toolkit
por: Lamanna, Jacopo, et al.
Publicado: (2022)

Non-neuronal, slow GABA signalling in the ventrobasal thalamus targets δ-subunit-containing GABA(A) receptors
por: Jiménez-González, Cristina, et al.
Publicado: (2011)

Hyperpolarization-activated ion channels as targets for nitric oxide signalling in deep cerebellar nuclei
por: Wilson, Gary W, et al.
Publicado: (2010)

Charge compensation for NADPH oxidase activity in microglia in rat brain slices does not involve a proton current
por: De Simoni, Anna, et al.
Publicado: (2008)

M-type channels selectively control bursting in rat dopaminergic neurons
por: Drion, Guillaume, et al.
Publicado: (2010)

Intrinsic subthreshold oscillations extend the influence of inhibitory synaptic inputs on cortical pyramidal neurons
por: Stiefel, Klaus M, et al.
Publicado: (2010)

Decoding glutamate receptor activation by the Ca(2+) sensor protein hippocalcin in rat hippocampal neurons
por: Dovgan, A V, et al.
Publicado: (2010)

Role of protein kinase C and μ-opioid receptor (MOPr) desensitization in tolerance to morphine in rat locus coeruleus neurons
por: Bailey, C P, et al.
Publicado: (2009)

Serotonin excites fast-spiking interneurons in the striatum
por: Blomeley, Craig P, et al.
Publicado: (2009)

Induction and expression of GluA1 (GluR-A)-independent LTP in the hippocampus
por: Romberg, Carola, et al.
Publicado: (2009)

Maintaining network activity in submerged hippocampal slices: importance of oxygen supply
por: Hájos, Norbert, et al.
Publicado: (2009)

Sensory and cortical activation of distinct glial cell subtypes in the somatosensory thalamus of young rats
por: Parri, H Rheinallt, et al.
Publicado: (2010)

Unique somato-dendritic distribution pattern of Kv4.2 channels on hippocampal CA1 pyramidal cells
por: Kerti, Katalin, et al.
Publicado: (2012)

Fast oscillatory activity induced by kainate receptor activation in the rat basolateral amygdala in vitro
por: Randall, Fiona E, et al.
Publicado: (2011)

Role of P2X4 receptors in synaptic strengthening in mouse CA1 hippocampal neurons
por: Baxter, Andrew W, et al.
Publicado: (2011)

μ-Opioid receptor desensitization: homologous or heterologous?
por: Llorente, Javier, et al.
Publicado: (2012)

MicroRNA-132 regulates recognition memory and synaptic plasticity in the perirhinal cortex
por: Scott, Helen L, et al.
Publicado: (2012)

Loss of the calcium channel β(4) subunit impairs parallel fibre volley and Purkinje cell firing in cerebellum of adult ataxic mice
por: Benedetti, Bruno, et al.
Publicado: (2016)

Ionotropic glutamate receptor GluA4 and T‐type calcium channel Ca(v)3.1 subunits control key aspects of synaptic transmission at the mouse L5B‐POm giant synapse
por: Seol, Min, et al.
Publicado: (2015)

Nasal obstruction during the growth period modulates the Wnt/β‐catenin pathway and brain‐derived neurotrophic factor production in association with tyrosine kinase receptor B mRNA reduction in mouse hippocampus
por: Ishidori, Hideyuki, et al.
Publicado: (2021)

Early glycogen synthase kinase‐3β and protein phosphatase 2A independent tau dephosphorylation during global brain ischaemia and reperfusion following cardiac arrest and the role of the adenosine monophosphate kinase pathway
por: Majd, Shohreh, et al.
Publicado: (2016)

The TIR-domain-containing adapter inducing interferon-β-dependent signaling cascade plays a crucial role in ischemia–reperfusion-induced retinal injury, whereas the contribution of the myeloid differentiation primary response 88-dependent signaling cascade is not as pivotal
por: Dvoriantchikova, Galina, et al.
Publicado: (2014)

AMPA Receptor Function in Hypothalamic Synapses
por: Royo, Maria, et al.
Publicado: (2022)

Nano-Organization at the Synapse: Segregation of Distinct Forms of Neurotransmission
por: Guzikowski, Natalie J., et al.
Publicado: (2021)

Synapse Type-Dependent Expression of Calcium-Permeable AMPA Receptors
por: Lalanne, Txomin, et al.
Publicado: (2018)

Dopamine suppresses persistent network activity via D(1)-like dopamine receptors in rat medial entorhinal cortex
por: Mayne, Elizabeth W, et al.
Publicado: (2013)

Protein kinase C regulates tonic GABA(A) receptor-mediated inhibition in the hippocampus and thalamus
por: Bright, Damian P, et al.
Publicado: (2013)

Tumor necrosis factor-alpha mediates activation of NF-κB and JNK signaling cascades in retinal ganglion cells and astrocytes in opposite ways
por: Dvoriantchikova, Galina, et al.
Publicado: (2014)

Mechanisms regulating spill‐over of synaptic glutamate to extrasynaptic NMDA receptors in mouse substantia nigra dopaminergic neurons
por: Wild, A. R., et al.
Publicado: (2015)

The extremely broad odorant response profile of mouse olfactory sensory neurons expressing the odorant receptor MOR256‐17 includes trace amine‐associated receptor ligands
por: Tazir, Bassim, et al.
Publicado: (2016)

The general anaesthetic etomidate inhibits the excitability of mouse thalamocortical relay neurons by modulating multiple modes of GABA(A) receptor-mediated inhibition
por: Herd, Murray B, et al.
Publicado: (2014)

Role of G(o/i) subgroup of G proteins in olfactory signaling of Drosophila melanogaster
por: Ignatious Raja, Jennifer S, et al.
Publicado: (2014)

Stimulus intensity determines experience-dependent modifications in neocortical neuron firing rates
por: Glazewski, Stanislaw, et al.
Publicado: (2015)

Shedding light on mitochondrial movements in axons (Commentary on Obashi & Okabe)
por: Vaccaro, Victoria, et al.
Publicado: (2013)

Brain‐derived neurotrophic factor prevents dendritic retraction of adult mouse retinal ganglion cells
por: Binley, Kate E., et al.
Publicado: (2016)

Ryanodine‐sensitive intracellular Ca(2+) channels are involved in the output from the SCN circadian clock
por: Aguilar‐Roblero, Raúl, et al.
Publicado: (2016)

Microglia‐derived purines modulate mossy fibre synaptic transmission and plasticity through P2X(4) and A(1) receptors
por: George, Jimmy, et al.
Publicado: (2016)

Essential role of endogenous calcitonin gene‐related peptide in pain‐associated plasticity in the central amygdala
por: Shinohara, Kei, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_h646u0imn1k7mfbr5jfthj9ucq