Bromodomain and extra‐terminal protein mimic JQ1 decreases inflammation in human vascular endothelial cells: Implications for pulmonary arterial hypertension

BACKGROUND AND OBJECTIVE: Nuclear factor kappa B (NF‐kB)‐mediated inflammatory gene expression and vascular endothelial cell proliferation/remodelling are implicated in the pathophysiology of the fatal disease, pulmonary arterial hypertension (PAH). Bromodomain and extra‐terminal (BET) proteins are...

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Detalles Bibliográficos
Autores principales: Mumby, Sharon, Gambaryan, Natalia, Meng, Chao, Perros, Frederic, Humbert, Marc, Wort, S. John, Adcock, Ian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2016
Materias:
ORIGINAL ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215513/
https://www.ncbi.nlm.nih.gov/pubmed/27539364
http://dx.doi.org/10.1111/resp.12872

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215513/
https://www.ncbi.nlm.nih.gov/pubmed/27539364
http://dx.doi.org/10.1111/resp.12872

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