Riluzole But Not Melatonin Ameliorates Acute Motor Neuron Degeneration and Moderately Inhibits SOD1-Mediated Excitotoxicity Induced Disrupted Mitochondrial Ca(2+) Signaling in Amyotrophic Lateral Sclerosis

Selective motoneurons (MNs) degeneration in the brain stem, hypoglossal motoneurons (HMNs), and the spinal cord resulting in patients paralysis and eventual death are prominent features of amyotrophic lateral sclerosis (ALS). Previous studies have suggested that mitochondrial respiratory impairment,...

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Detalles Bibliográficos
Autor principal: Jaiswal, Manoj Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216043/
https://www.ncbi.nlm.nih.gov/pubmed/28111541
http://dx.doi.org/10.3389/fncel.2016.00295

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216043/
https://www.ncbi.nlm.nih.gov/pubmed/28111541
http://dx.doi.org/10.3389/fncel.2016.00295

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